Quantitative Methods For Traditional Chinese Medicine Development

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Quantitative Methods For Traditional Chinese Medicine Development


Quantitative Methods For Traditional Chinese Medicine Development
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Quantitative Methods For Traditional Chinese Medicine Development


Quantitative Methods For Traditional Chinese Medicine Development
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Author : Shein-Chung Chow
language : en
Publisher: CRC Press
Release Date : 2019-09-05

Quantitative Methods For Traditional Chinese Medicine Development written by Shein-Chung Chow and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-09-05 with Medicine, Chinese categories.


A Western-Based Approach to Analyzing TCMs In recent years, many pharmaceutical companies and clinical research organizations have been focusing on the development of traditional Chinese (herbal) medicines (TCMs) as alternatives to treating critical or life-threatening diseases and as pathways to personalized medicine. Quantitative Methods for Traditional Chinese Medicine Development is the first book entirely devoted to the design and analysis of TCM development from a Western perspective, i.e., evidence-based clinical research and development. The book provides not only a comprehensive summary of innovative quantitative methods for developing TCMs but also a useful desk reference for principal investigators involved in personalized medicine. Written by one of the world's most prominent biostatistics researchers, the book connects the pharmaceutical industry, regulatory agencies, and academia. It presents a state-of-the-art examination of the subject for: Scientists and researchers who are engaged in pharmaceutical/clinical research and development of TCMs Those in regulatory agencies who make decisions in the review and approval process of TCM regulatory submissions Biostatisticians who provide statistical support to assess clinical safety and effectiveness of TCMs and related issues regarding quality control and assurance as well as to test for consistency in the manufacturing processes for TCMs This book covers all of the statistical issues encountered at various stages of pharmaceutical/clinical development of a TCM. It explains regulatory requirements; product specifications and standards; and various statistical techniques for evaluation of TCMs, validation of diagnostic procedures, and testing consistency. It also contains an entire chapter of case studies and addresses critical issues in TCM development and FAQs from a

Data Analytics For Traditional Chinese Medicine Research


Data Analytics For Traditional Chinese Medicine Research
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Author : Josiah Poon
language : en
Publisher: Springer Science & Business Media
Release Date : 2014-02-19

Data Analytics For Traditional Chinese Medicine Research written by Josiah Poon and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-02-19 with Computers categories.


This contributed volume explores how data mining, machine learning, and similar statistical techniques can analyze the types of problems arising from Traditional Chinese Medicine (TCM) research. The book focuses on the study of clinical data and the analysis of herbal data. Challenges addressed include diagnosis, prescription analysis, ingredient discoveries, network based mechanism deciphering, pattern-activity relationships, and medical informatics. Each author demonstrates how they made use of machine learning, data mining, statistics and other analytic techniques to resolve their research challenges, how successful if these techniques were applied, any insight noted and how these insights define the most appropriate future work to be carried out. Readers are given an opportunity to understand the complexity of diagnosis and treatment decision, the difficulty of modeling of efficacy in terms of herbs, the identification of constituent compounds in an herb, the relationship between these compounds and biological outcome so that evidence-based predictions can be made. Drawing on a wide range of experienced contributors, Data Analytics for Traditional Chinese Medicine Research is a valuable reference for professionals and researchers working in health informatics and data mining. The techniques are also useful for biostatisticians and health practitioners interested in traditional medicine and data analytics.

Quantitative Methods For Traditional Chinese Medicine Development


Quantitative Methods For Traditional Chinese Medicine Development
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Author : Shein-Chung Chow
language : en
Publisher: CRC Press
Release Date : 2015-10-15

Quantitative Methods For Traditional Chinese Medicine Development written by Shein-Chung Chow and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-10-15 with Health & Fitness categories.


A Western-Based Approach to Analyzing TCMs In recent years, many pharmaceutical companies and clinical research organizations have been focusing on the development of traditional Chinese (herbal) medicines (TCMs) as alternatives to treating critical or life-threatening diseases and as pathways to personalized medicine. Quantitative Methods for Traditional Chinese Medicine Development is the first book entirely devoted to the design and analysis of TCM development from a Western perspective, i.e., evidence-based clinical research and development. The book provides not only a comprehensive summary of innovative quantitative methods for developing TCMs but also a useful desk reference for principal investigators involved in personalized medicine. Written by one of the world’s most prominent biostatistics researchers, the book connects the pharmaceutical industry, regulatory agencies, and academia. It presents a state-of-the-art examination of the subject for: Scientists and researchers who are engaged in pharmaceutical/clinical research and development of TCMs Those in regulatory agencies who make decisions in the review and approval process of TCM regulatory submissions Biostatisticians who provide statistical support to assess clinical safety and effectiveness of TCMs and related issues regarding quality control and assurance as well as to test for consistency in the manufacturing processes for TCMs This book covers all of the statistical issues encountered at various stages of pharmaceutical/clinical development of a TCM. It explains regulatory requirements; product specifications and standards; and various statistical techniques for evaluation of TCMs, validation of diagnostic procedures, and testing consistency. It also contains an entire chapter of case studies and addresses critical issues in TCM development and FAQs from a regulatory perspective.

Modern Computational Approaches To Traditional Chinese Medicine


Modern Computational Approaches To Traditional Chinese Medicine
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Author : Zhaohui Wu
language : en
Publisher: Elsevier
Release Date : 2012-07-16

Modern Computational Approaches To Traditional Chinese Medicine written by Zhaohui Wu and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-07-16 with Computers categories.


Recognized as an essential component of Chinese culture, Traditional Chinese Medicine (TCM) is both an ancient medical system and one still used widely in China today. TCM's independently evolved knowledge system is expressed mainly in the Chinese language and the information is frequently only available through ancient classics and confidential family records, making it difficult to utilize. The major concern in TCM is how to consolidate and integrate the data, enabling efficient retrieval and discovery of novel knowledge from the dispersed data. Computational approaches such as data mining, semantic reasoning and computational intelligence have emerged as innovative approaches for the reservation and utilization of this knowledge system. Typically, this requires an inter-disciplinary approach involving Chinese culture, computer science, modern healthcare and life sciences. This book examines the computerization of TCM information and knowledge to provide intelligent resources and supporting evidences for clinical decision-making, drug discovery, and education. Recent research results from the Traditional Chinese Medicine Informatics Group of Zhejiang University are presented, gathering in one resource systematic approaches for massive data processing in TCM. These include the utilization of modern Semantic Web and data mining methods for more advanced data integration, data analysis and integrative knowledge discovery. This book will appeal to medical professionals, life sciences students, computer scientists, and those interested in integrative, complementary, and alternative medicine. Interdisciplinary book bringing together Traditional Chinese Medicine and computer scientists Introduces novel network technologies to Traditional Chinese Medicine informatics Provides theory and practical examples and case studies of new techniques

Systems Biology For Traditional Chinese Medicine


Systems Biology For Traditional Chinese Medicine
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Author : Guoan Luo
language : en
Publisher: John Wiley & Sons
Release Date : 2012-05-11

Systems Biology For Traditional Chinese Medicine written by Guoan Luo and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-05-11 with Science categories.


The application of systems biology methods to TraditionalChinese Medicine Emphasizing the harmony of the human body with the environment,Traditional Chinese Medicine (TCM) has evolved over thousands ofyears. It is a systemic theory derived from clinical experience,the philosophy of holism and systematology, and the belief that manis an integral part of nature. Systems Biology for Traditional Chinese Medicinedescribes how the latest methods in systems biology can be appliedto TCM, providing a comprehensive resource for the modernizationand advancement of TCM as well as general drug discovery efforts.It is the first comprehensive work to propose a system-to-systemresearch methodology to study the interaction between TCM and thehuman body and its applications in drug research anddevelopment. Using three popular traditional Chinesemedicines—Shuanglongfang, Qingkailing, andLiushenwan—as examples, the authors set forth case examplesdemonstrating how to find material groups, perform efficacyscreenings, and conduct safety evaluations of TCM. The bookalso: Describes the mechanisms of TCM at the molecular and systemslevels using chemomics, genomics, proteomics, metabolomics, andbioinformatics Places modern scientific technologies within the context ofTCM, helping drug researchers improve experimental designs andstrategies Illustrates how a systems biology approach is compatible withTCM's traditional, holistic therapeutic strategies and treatmentmodalities Presents topics of current interest, such as integrated globalsystems biology and the application of chemometrics research toherbal medicines This book not only opens a new pathway for the continueddevelopment of TCM, but also for systems biology. In addition, itfosters collaboration and discussion among Eastern and Westernscientists by applying systems biology to TCM.

Analytical Similarity Assessment In Biosimilar Product Development


Analytical Similarity Assessment In Biosimilar Product Development
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Author : Shein-Chung Chow
language : en
Publisher: CRC Press
Release Date : 2018-09-03

Analytical Similarity Assessment In Biosimilar Product Development written by Shein-Chung Chow and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-09-03 with Mathematics categories.


This book focuses on analytical similarity assessment in biosimilar product development following the FDA’s recommended stepwise approach for obtaining totality-of-the-evidence for approval of biosimilar products. It covers concepts such as the tiered approach for assessment of similarity of critical quality attributes in the manufacturing process of biosimilar products, models/methods like the statistical model for classification of critical quality attributes, equivalence tests for critical quality attributes in Tier 1 and the corresponding sample size requirements, current issues, and recent developments in analytical similarity assessment.

Quantitative Methods For Hiv Aids Research


Quantitative Methods For Hiv Aids Research
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Author : Cliburn Chan
language : en
Publisher: CRC Press
Release Date : 2017-08-07

Quantitative Methods For Hiv Aids Research written by Cliburn Chan and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-08-07 with Mathematics categories.


Quantitative Methods in HIV/AIDS Research provides a comprehensive discussion of modern statistical approaches for the analysis of HIV/AIDS data. The first section focuses on statistical issues in clinical trials and epidemiology that are unique to or particularly challenging in HIV/AIDS research; the second section focuses on the analysis of laboratory data used for immune monitoring, biomarker discovery and vaccine development; the final section focuses on statistical issues in the mathematical modeling of HIV/AIDS pathogenesis, treatment and epidemiology. This book brings together a broad perspective of new quantitative methods in HIV/AIDS research, contributed by statisticians and mathematicians immersed in HIV research, many of whom are current or previous leaders of CFAR quantitative cores. It is the editors’ hope that the work will inspire more statisticians, mathematicians and computer scientists to collaborate and contribute to the interdisciplinary challenges of understanding and addressing the AIDS pandemic.